NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.

  title={NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells.},
  author={Mamoru Ito and Hidefumi Hiramatsu and Kimio Kobayashi and Kazutomo Suzue and Mariko Kawahata and Kyoji Hioki and Y. Ueyama and Yoshio Koyanagi and Kazuo Sugamura and Kohichiro Tsuji and Toshio Heike and Tatsutoshi Nakahata},
  volume={100 9},
To establish a more appropriate animal recipient for xenotransplantation, NOD/SCID/gamma(c)(null) mice double homozygous for the severe combined immunodeficiency (SCID) mutation and interleukin-2Rgamma (IL-2Rgamma) allelic mutation (gamma(c)(null)) were generated by 8 backcross matings of C57BL/6J-gamma(c)(null) mice and NOD/Shi-scid mice. When human CD34+ cells from umbilical cord blood were transplanted into this strain, the engraftment rate in the peripheral circulation, spleen, and bone… CONTINUE READING
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