NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.

@article{Shultz2000NODLtSzRag1nullMA,
  title={NOD/LtSz-Rag1null mice: an immunodeficient and radioresistant model for engraftment of human hematolymphoid cells, HIV infection, and adoptive transfer of NOD mouse diabetogenic T cells.},
  author={Leonard D Shultz and Pamela A. Lang and Sherri W. Christianson and Bruce Gott and Bonnie L. Lyons and Syuji Umeda and Edward H. Leiter and Ruth Hesselton and Eric J. Wagar and Jean H. Leif and O Kollet and Tsvee Lapidot and Dale L. Greiner},
  journal={Journal of immunology},
  year={2000},
  volume={164 5},
  pages={2496-507}
}
Development of a small animal model for the in vivo study of human immunity and infectious disease remains an important goal, particularly for investigations of HIV vaccine development. NOD/Lt mice homozygous for the severe combined immunodeficiency (Prkdcscid) mutation readily support engraftment with high levels of human hematolymphoid cells. However, NOD/LtSz-scid mice are highly radiosensitive, have short life spans, and a small number develop functional lymphocytes with age. To overcome… CONTINUE READING