NOA1 is an essential GTPase required for mitochondrial protein synthesis

  title={NOA1 is an essential GTPase required for mitochondrial protein synthesis},
  author={Mateusz Kolanczyk and Markus Pech and Tomasz Zemojtel and Hiroshi Yamamoto and Ivan Mikula and Maria-Antonietta Calvaruso and Mari{\"e}l A. M. van den Brand and Ricarda Richter and Bjoern Fischer and Anita Ritz and Nadine Kossler and Boris Thurisch and Ralf Spoerle and Jan A M Smeitink and Uwe Kornak and Danny Chan and Martin Vingron and P Martasek and Robert N Lightowlers and Leo G. J. Nijtmans and Markus Schuelke and Knud H. Nierhaus and Stefan Mundlos},
  booktitle={Molecular biology of the cell},
Nitric oxide associated-1 (NOA1) is an evolutionarily conserved guanosine triphosphate (GTP) binding protein that localizes predominantly to mitochondria in mammalian cells. On the basis of bioinformatic analysis, we predicted its possible involvement in ribosomal biogenesis, although this had not been supported by any experimental evidence. Here we determine NOA1 function through generation of knockout mice and in vitro assays. NOA1-deficient mice exhibit midgestation lethality associated with… CONTINUE READING
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