NO2 reactive absorption substrates in rat pulmonary surface lining fluids.

@article{Postlethwait1995NO2RA,
  title={NO2 reactive absorption substrates in rat pulmonary surface lining fluids.},
  author={Edward M. Postlethwait and Shannon D. Langford and Lynn M. Jacobson and Akhil Bidani},
  journal={Free radical biology & medicine},
  year={1995},
  volume={19 5},
  pages={553-63}
}
Inhaled 'NO2 is absorbed by a free radical-dependent reaction mechanism that localizes the initial oxidative events to the extracellular space of the pulmonary surface lining layer (SLL). Because 'NO2 per se is eliminated upon absorption, most likely the SLL-derived reaction products are critical to the genesis of 'NO2-induced lung injury. We utilized analysis of the rate of 'NO2 disappearance from the gas phase to determine the preferential absorption substrates within rat SLL. SLL was… CONTINUE READING
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