NO2-induced generation of extracellular reactive oxygen is mediated by epithelial lining layer antioxidants.

@article{Velsor1997NO2inducedGO,
  title={NO2-induced generation of extracellular reactive oxygen is mediated by epithelial lining layer antioxidants.},
  author={Leonard W Velsor and Edward M. Postlethwait},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1997},
  volume={273 6},
  pages={L1265-L1275}
}
Nitrogen dioxide (NO2) is an environmental oxidant that causes acute lung injury. Absorption of this aqueous insoluble gas into the epithelial lining fluid (ELF) that covers air space surfaces is, in part, governed by reactions with ELF constituents. Consequently, NO2absorption is coupled to its chemical elimination and the formation of ELF-derived products. To investigate mechanisms of acute epithelial injury, we developed a model encompassing the spatial arrangements of the lung surface… CONTINUE READING

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Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo.

  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2009
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