NO synthase activity does not influence electrical activity of mouse pancreatic B-cells.

@article{Drews1995NOSA,
  title={NO synthase activity does not influence electrical activity of mouse pancreatic B-cells.},
  author={Gisela Drews and Peter Krippeit-Drews},
  journal={Biochemical and biophysical research communications},
  year={1995},
  volume={210 3},
  pages={914-20}
}
The membrane potential of mouse pancreatic B-cells was recorded with intracellular microelectrodes. At a low concentration the NO synthase inhibitor N omega-nitro-L-arginine methyl ester (L-NAME, 100 mumol/l) did not alter electrical activity induced by 15 mmol/l glucose. At 5 mmol/l L-NAME depolarized B-cells similarly to L-arginine. The depolarization of… CONTINUE READING