NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.

@article{Lin2004NOSO,
  title={NO stimulation of ATP-sensitive potassium channels: Involvement of Ras/mitogen-activated protein kinase pathway and contribution to neuroprotection.},
  author={Y F Lin and Kimberly F. Raab-Graham and Yuh Nung Jan and Lily Yeh Jan},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 20},
  pages={7799-804}
}
ATP-sensitive potassium (K(ATP)) channels regulate insulin release, vascular tone, and neuronal excitability. Whether these channels are modulated by NO, a membrane-permeant messenger in various physiological and pathological processes, is not known. The possibility of NO signaling via K(ATP) channel modulation is of interest because both NO and K(ATP) have been implicated in physiological functions such as vasodilation and neuroprotection. In this report, we demonstrate a mechanism that leads… CONTINUE READING

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