NO signalling decodes frequency of neuronal activity and generates synapse‐specific plasticity in mouse cerebellum

@article{Namiki2005NOSD,
  title={NO signalling decodes frequency of neuronal activity and generates synapse‐specific plasticity in mouse cerebellum},
  author={Shigeyuki Namiki and Sho Kakizawa and Kenzo Hirose and Masamitsu Iino},
  journal={The Journal of Physiology},
  year={2005},
  volume={566}
}
Nitric oxide (NO) is an intercellular messenger regulating neuronal functions. To visualize NO signalling in the brain, we generated a novel fluorescent NO indicator, which consists of the heme‐binding region (HBR) of soluble guanylyl cyclase and the green fluorescent protein. The indicator (HBR–GFP) was expressed in the Purkinje cells of the mouse cerebellum and we imaged NO signals in acute cerebellar slices upon parallel fibre (PF) activation with a train of burst stimulations (BS, each BS… 

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