NO pathway in CF and non-CF children.

@article{Wooldridge2004NOPI,
  title={NO pathway in CF and non-CF children.},
  author={Jamie L. Wooldridge and Gail Deutsch and Marci K Sontag and Iris Osberg and Daniel Chase and Philip E Silkoff and Jeffery S Wagener and Steven H Abman and Frank Accurso},
  journal={Pediatric pulmonology},
  year={2004},
  volume={37 4},
  pages={
          338-50
        }
}
Controversy exists concerning abnormalities of the nitric oxide (NO) pathway in cystic fibrosis (CF) lung disease. Although some studies suggested that NO activity is impaired in CF, changes in NO production in young children have not been studied. We hypothesized that nitric oxide synthase (NOS II) expression is decreased in young children with CF, leading to decreased production of lower airway NO, and that decreased NOS II expression is related to airway inflammation. Accordingly, we… CONTINUE READING

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