NO news from insect brains.

  title={NO news from insect brains.},
  author={Gerd Bicker},
  journal={Trends in neurosciences},
  volume={21 8},
In nerve cells,the short-lived signalling molecule nitric oxide (NO) is generated by Ca2+-calmodulin-stimulated NO synthases. Nitric oxide activates soluble guanylate cyclase in target cells, leading to the formation of cGMP. Biochemical investigations have shown the presence of a Ca2+-calmodulin-regulated NO-cGMP signalling mechanism in the nervous system of insects. Using NADPH-diaphorase staining as a marker for the enzyme NO synthase and an antiserum against cGMP,the cellular organization… CONTINUE READING