NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis.

@article{Cicala2000NOnaproxenMI,
  title={NO-naproxen modulates inflammation, nociception and downregulates T cell response in rat Freund's adjuvant arthritis.},
  author={Carla Cicala and Angela Ianaro and Stefano Fiorucci and A Calignano and Mariarosaria Bucci and Renato Gerli and Luca Santucci and John L Wallace and Giuseppe Antonio Cirino},
  journal={British journal of pharmacology},
  year={2000},
  volume={130 6},
  pages={1399-405}
}
1. Anti-inflammatory non steroidal drugs releasing NO (NO-NSAIDs) are a new class of anti-inflammatory drugs to which has been added an NO-releasing moiety. These compounds have been shown to retain the anti-inflammatory, analgesic and antipyretic activity of the parent compound but to be devoid of gastrointestinal (GI) toxicity. 2. Freund's adjuvant (FA) arthritis was induced in rats by a single intraplantar injection into the right hindpaw of 100 microl of mycobacterium butirricum (6 mg ml(-1… CONTINUE READING

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