NO modulates myocardial O2 consumption in the nonhuman primate: an additional mechanism of action of amlodipine.

@article{Forfia1999NOMM,
  title={NO modulates myocardial O2 consumption in the nonhuman primate: an additional mechanism of action of amlodipine.},
  author={Paul R. Forfia and Xiaoping Zhang and Delvin R. Knight and Anne H. Smith and Christopher P A Doe and Eric A. Wolfgang and David M. Flynn and Michael S. Wolin and Thomas H. Hintze},
  journal={The American journal of physiology},
  year={1999},
  volume={276 6},
  pages={
          H2069-75
        }
}
Recent evidence from our laboratory and others suggests that nitric oxide (NO) is a modulator of in vivo and in vitro oxygen consumption in the murine and canine heart. Therefore, the goal of our study was twofold: to determine whether NO modulates myocardial oxygen consumption in the nonhuman primate heart in vitro and to evaluate whether the seemingly cardioprotective actions of amlodipine may involve an NO-mediated mechanism. Using a Clark-type O2 electrode, we measured oxygen consumption in… Expand
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