NO-mediated vasodilation in the rat liver. Role of hepatocytes and liver endothelial cells.

@article{Zhang1997NOmediatedVI,
  title={NO-mediated vasodilation in the rat liver. Role of hepatocytes and liver endothelial cells.},
  author={Bao-xu Zhang and Didier Borderie and Phillippe Sogni and Olivier Soubrane and Didier P Houssin and Yvon Calmus},
  journal={Journal of hepatology},
  year={1997},
  volume={26 6},
  pages={1348-55}
}
BACKGROUND/AIMS Nitric oxide (NO) is a potent vasodilator. We investigated the mechanisms responsible for this effect in the liver. METHODS Isolated perfused rat liver and cultures of endothelial sinusoidal cells and hepatocytes were used. RESULTS L-arginine (10(-3) M) and NO donor Sin-1 (10(-5) M) respectively increased the liver flow by 52% (p<0.01) and 93% (p<0.01) vs controls. The NO synthase inhibitor Nw-nitro-L-arginine (10(-3) M) and the guanylate cyclase inhibitor methylene blue (10… CONTINUE READING

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