NO is not involved in the simvastatin induced cell division and differentiation in PC12 cells.

@article{Sano1998NOIN,
  title={NO is not involved in the simvastatin induced cell division and differentiation in PC12 cells.},
  author={Motoaki Sano and I Sato-Suzuki and Hiroshi Fujita and Ikuo Morita and Minako Nagao and Se-itsu Murota},
  journal={Neuroscience letters},
  year={1998},
  volume={243 1-3},
  pages={73-6}
}
Simvastatin, a potent 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor has been reported to inhibit cell division and induce neurite-like outgrowth in PC12 cells [Sato-Suzuki, I. and Murota, S., Neurosci. Lett., 220 (1996) 21-24]. In the present paper, we examined whether the induced nitric oxide (NO) in the simvastatin-treated PC12 cells is involved in the growth arrest and differentiation as reported in nerve growth factor (NGF) treated PC12 cells. Treatment of PC12 cells… CONTINUE READING

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