NO-independent mechanism mediates tempol-induced renal vasodilation in SHR.

@article{deRichelieu2005NOindependentMM,
  title={NO-independent mechanism mediates tempol-induced renal vasodilation in SHR.},
  author={Louise Tilma de Richelieu and Charlotte Mehlin S{\o}rensen and Niels-Henrik Holstein-Rathlou and Max Salomonsson},
  journal={American journal of physiology. Renal physiology},
  year={2005},
  volume={289 6},
  pages={
          F1227-34
        }
}
We investigated whether tempol, a superoxide dismutase mimetic, affected renal hemodynamics and arterial pressure in spontaneously hypertensive rats (SHR) and Sprague-Dawley (SD) rats. We also examined whether tempol affected exaggerated renal vasoconstrictor responses to ANG II in SHR. To test whether the effects of tempol were due to a restored NO system, we used the NOS inhibitor N(w)-nitro-L-arginine methyl ester (L-NAME). Renal blood flow (RBF) and mean arterial pressure (MAP) were… 
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