NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy.

@article{Kalk2006NOindependentAO,
  title={NO-independent activation of soluble guanylate cyclase prevents disease progression in rats with 5/6 nephrectomy.},
  author={Philipp Kalk and Michael Godes and Katharina Relle and Christiane Rothkegel and Andreas Hucke and J. -P. Stasch and Berthold Hocher},
  journal={British journal of pharmacology},
  year={2006},
  volume={148 6},
  pages={853-9}
}
1. Chronic renal disease is associated with oxidative stress, reduced nitric oxide (NO) availability and soluble guanylate cyclase (sGC) dysfunction. Recently, we discovered BAY 58-2667, a compound activating heme-deficient or oxidized sGC in a NO-independent manner. 2. We assessed potential of BAY 58-2667 in preventing cardiac and renal target organ damage in rats with 5/6 nephrectomy. 3. Male Wistar rats were allocated to three groups: 5/6 nephrectomy, 5/6 nephrectomy treated with BAY 58-2667… CONTINUE READING

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