NO-dependent vasorelaxation is impaired after gene transfer of inducible NO-synthase.

@article{Gunnett2001NOdependentVI,
  title={NO-dependent vasorelaxation is impaired after gene transfer of inducible NO-synthase.},
  author={Carol A Gunnett and D. Lund and Yi Jun Chu and Robert M. Brooks and Frank M. Faraci and Donald D. Heistad},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 8},
  pages={1281-7}
}
Proinflammatory stimuli produce expression of inducible NO-synthase (iNOS) within blood vessels and are associated with impaired endothelium-dependent relaxation. Gene transfer of iNOS was used to test the hypothesis that expression of iNOS in blood vessels produces impairment of NO-dependent relaxation as well as contraction. An adenoviral vector containing cDNA for murine iNOS, AdCMViNOS, and a control virus, AdCMVBglII, were used for gene transfer to rabbit carotid arteries in vitro and in… CONTINUE READING
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