NO-dependent and NO-independent IL-1 production by a human colonic epithelial cell line under inflammatory stress.

@article{Vallette1997NOdependentAN,
  title={NO-dependent and NO-independent IL-1 production by a human colonic epithelial cell line under inflammatory stress.},
  author={Genevi{\`e}ve Vallette and Anne Charlotte Jarry and Philippe Lemarre and J E Branka and Christian L. Laboisse},
  journal={British journal of pharmacology},
  year={1997},
  volume={121 2},
  pages={187-92}
}
1. The present study was designed to investigate, in an in vitro model of the human intestinal barrier, the ability of epithelial cells to produce interleukin-1 (IL-1), the cellular mechanisms involved in IL-1 release, and the intracellular signalling pathways involved in IL-1 up-regulation during inflammatory stress. 2. This study was based on the human colonic epithelial cell line HT29-Cl.16E, maintained as polarized monolayers on filters mounted in culture chambers and treated with various… CONTINUE READING