NO-cGMP and TNF-alpha counter regulatory system in blood: understanding the mechanisms leading to myocardial dysfunction and failure.

@article{Elahi2007NOcGMPAT,
  title={NO-cGMP and TNF-alpha counter regulatory system in blood: understanding the mechanisms leading to myocardial dysfunction and failure.},
  author={Maqsood M. Elahi and Sanjay Asopa and Bashir Matata},
  journal={Biochimica et biophysica acta},
  year={2007},
  volume={1772 1},
  pages={5-14}
}
One of the major conceptual advances in the understanding of the pathogenesis of heart failure has been the insight that myocardial dysfunction and heart failure may progress as the result of the sustained over-expression of nitric oxide (NO) metabolites locally and in blood modulated by inducible nitric oxide synthase (iNOS). This by virtue of their deleterious effects is sufficient to contribute to disease progression by provoking left ventricular (LV) remodeling, hypertrophy and progressive… CONTINUE READING

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