NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines.

@article{Fiorucci2000NOaspirinPF,
  title={NO-aspirin protects from T cell-mediated liver injury by inhibiting caspase-dependent processing of Th1-like cytokines.},
  author={Stefano Fiorucci and Luca Santucci and Elisabetta Antonelli and Eleonora Distrutti and Giuseppe Del Sero and Olivia Morelli and Luigina Romani and Barbara Federici and Piero del Soldato and Antonio Morelli},
  journal={Gastroenterology},
  year={2000},
  volume={118 2},
  pages={404-21}
}
BACKGROUND & AIMS Concanavalin A (con A)-induced hepatitis is an immunomediated disease in which assembly of CD4(+) T cells and T helper (Th)1-like cytokines causes Fas-mediated liver cell death. Nitric oxide (NO) modulates Th1 response in vitro. NCX-4016 is an NO-aspirin derivative that spares the gastrointestinal tract and shares molecular targets with NO… CONTINUE READING