NO and endogenous angiotensin II interact in the generation of renal sympathetic nerve activity in conscious rats.

@article{McKeogh2004NOAE,
  title={NO and endogenous angiotensin II interact in the generation of renal sympathetic nerve activity in conscious rats.},
  author={Donogh F McKeogh and Theresa L. O'Donaughy and Virginia Leah Brooks},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2004},
  volume={286 4},
  pages={H1258-65}
}
Nitric oxide (NO) appears to inhibit sympathetic tone in anesthetized rats. However, whether NO tonically inhibits sympathetic outflow, or whether endogenous angiotensin II (ANG II) promotes NO-mediated sympathoinhibition in conscious rats is unknown. To address these questions, we determined the effects of NO synthase (NOS) inhibition on renal sympathetic nerve activity (RSNA) and heart rate (HR) in conscious, unrestrained rats on normal (NS), high-(HS), and low-sodium (LS) diets, in the… CONTINUE READING