NO/cGMP: the past, the present, and the future.

  title={NO/cGMP: the past, the present, and the future.},
  author={Michael Russwurm and Corina Russwurm and Doris Koesling and Evanthia Mergia},
  journal={Methods in molecular biology},
The NO/cGMP signalling cascade participates in the regulation of physiological parameters such as smooth muscle relaxation, inhibition of platelet aggregation, and neuronal transmission. cGMP is formed in response to nitric oxide (NO) by NO-sensitive guanylyl cyclases that exist in two isoforms (NO-GC1 and NO-GC2). Much has been learned about the regulation of NO-GC; however the precise role of cGMP in complex physiological and especially in pathophysiological settings and its alteration by… CONTINUE READING


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