NNZ-2566: a Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke.

@article{Bickerdike2009NNZ2566AG,
  title={NNZ-2566: a Gly-Pro-Glu analogue with neuroprotective efficacy in a rat model of acute focal stroke.},
  author={Michael J Bickerdike and Gregory B Thomas and David Batchelor and Ernest S Sirimanne and Wing Leong and Hai Lin and Frank Sieg and Jingyuan Wen and Margaret A Brimble and Paul WR Harris and Peter Gluckman},
  journal={Journal of the neurological sciences},
  year={2009},
  volume={278 1-2},
  pages={85-90}
}
The N-terminal cleavage product of human insulin-like growth factor-1 (IGF-1) in the brain is the tripeptide molecule Glypromate (Gly-Pro-Glu). Glypromate has demonstrated neuroprotective effects in numerous in vitro and in vivo models of brain injury and is in clinical trials for the prevention of cognitive impairment following cardiac surgery. NNZ-2566 is… CONTINUE READING