NNZ-2566, a glypromate analog, improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury.

@article{Lu2009NNZ2566AG,
  title={NNZ-2566, a glypromate analog, improves functional recovery and attenuates apoptosis and inflammation in a rat model of penetrating ballistic-type brain injury.},
  author={Xi-chun May Lu and R Chen and Changping Yao and Hans H Wei and Xiaofang Yang and Zhilin Liao and Jitendra R. Dave and Frank C. Tortella},
  journal={Journal of neurotrauma},
  year={2009},
  volume={26 1},
  pages={141-54}
}
Glycine-proline-glutamate (GPE) is an N-terminal tripeptide endogenously cleaved from insulin-like growth factor-1 in the brain and is neuroprotective against hypoxic-ischemic brain injury and neurodegeneration. NNZ-2566 is an analog of GPE designed to have improved bioavailability. In this study, we tested NNZ-2566 in a rat model of penetrating ballistic-type brain injury (PBBI) and assessed its effects on injury-induced histopathology, behavioral deficits, and molecular and cellular events… CONTINUE READING
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