NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats.

@article{Lu2009NNZ2566AG,
  title={NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats.},
  author={Xi-chun May Lu and Yuanzheng Si and Antony J. Williams and Jed A. Hartings and Divina S Gryder and Frank C. Tortella},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2009},
  volume={29 12},
  pages={1924-32}
}
Ischemic and traumatic brain injuries often induce non-convulsive seizures (NCSs), which likely contribute to the worsening of neurological outcomes. Here, we evaluated the effect of glycyl-L-methylprolyl-L-glutamic acid (NNZ-2566) to lessen the severity of NCSs caused by permanent middle cerebral artery occlusion (pMCAo). Continuous electroencephalographic recordings were performed in rats during pMCAo. Glycyl-L-methylprolyl-L-glutamic acid (3, 10, or 100 mg/kg bolus followed by an infusion of… CONTINUE READING

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