NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome

  title={NNZ-2566, a Novel Analog of (1–3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome},
  author={R. Deacon and L. Glass and M. Snape and M. J. Hurley and Francisco Altimiras and Rodolfo R. Biekofsky and P. Cogram},
  journal={NeuroMolecular Medicine},
  • R. Deacon, L. Glass, +4 authors P. Cogram
  • Published 2015
  • Psychology, Medicine
  • NeuroMolecular Medicine
  • AbstractFragile X syndrome (FXS) is the most common form of inherited intellectual disability. Previous studies have implicated mGlu5 in the pathogenesis of the disease, and many agents that target the underlying pathophysiology of FXS have focused on mGluR5 modulation. In the present work, a novel pharmacological approach for FXS is investigated. NNZ-2566, a synthetic analog of a naturally occurring neurotrophic peptide derived from insulin-like growth factor-1 (IGF-1), was administered to… CONTINUE READING
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