NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice.

@article{Matsuda2019NNC5A,
  title={NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice.},
  author={Sachi Matsuda and Hiroyuki Nishikawa and Anna Fukatsu and Yuko Kurokawa and Maho Tsubota and Fumiko Sekiguchi and Shogo Tokuyama and Atsufumi Kawabata},
  journal={Journal of pharmacological sciences},
  year={2019}
}
We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced the MCAO/R-induced brain infarct and neurological dysfunctions, although it, given toward the end of occlusion, was less effective. Systemic administration of NNC before the occlusion also attenuated the infarct and neurological dysfunctions. Our data… CONTINUE READING