NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin.

  title={NMR studies on novel antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin.},
  author={C. H. Lee and Huang Hong and J. Shin and Manfred Jung and Injae Shin and J. Yoon and W. Lee},
  journal={Biochemical and biophysical research communications},
  volume={274 2},
  • C. LeeH. Hong W. Lee
  • Published 2 August 2000
  • Chemistry, Biology
  • Biochemical and biophysical research communications
Artemisinin and its derivatives, which have been known as antimalarial drugs, have also demonstrated their cytotoxicity against tumor cells. It has been proposed that antitumor activity depends on the lipophilicity of functional group on artemisinin derivatives. Solution structures of two artemisinin derivatives as antitumor drug candidates, deoxoartemisinin and carboxypropyldeoxoartemisinin, were determined by NMR spectroscopy to elucidate structure-activity relationship. According to… 

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