NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit.

@article{Beer1996NMRSO,
  title={NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit.},
  author={Tonny de Beer and C W van Zuylen and Bas R. Leeflang and Karl H{\aa}rd and Rolf Boelens and R. Kaptein and Johannis P. Kamerling and Johannes F. G. Vliegenthart},
  journal={European journal of biochemistry},
  year={1996},
  volume={241 1},
  pages={229-42}
}
Human chorionic gonadotropin (hCG) is a heterodimeric glycoprotein hormone that is involved in the maintenance of the corpus luteum in early pregnancy. Glycosylation at Asn52 of its alpha subunit (alpha hCG) is essential for signal transduction, whereas the N-glycan at Asn78 stabilizes the structure of the protein. In this study, an almost complete 1H-NMR… CONTINUE READING