NMR studies of protein surface accessibility.

  title={NMR studies of protein surface accessibility.},
  author={Neri Niccolai and Arianna Ciutti and Ottavia Spiga and Maria Scarselli and Andrea Bernini and Luisa Bracci and Daniela Di Maro and Claudio Dalvit and Henriette Molinari and Gennaro Esposito and Piero Andrea Temussi},
  journal={The Journal of biological chemistry},
  volume={276 45},
Characterization of protein surface accessibility represents a new frontier of structural biology. A surface accessibility investigation for two structurally well-defined proteins, tendamistat and bovine pancreatic trypsin inhibitor, is performed here by a combined analysis of water-protein Overhauser effects and paramagnetic perturbation profiles induced by the soluble spin-label 4-hydroxy-2,2,6,6-tetramethyl-piperidine-1-oxyl on NMR spectra. This approach seems to be reliable not only for… CONTINUE READING

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