NMR studies of flexible opiate conformations at monoclonal antibody binding sites. I. Transferred nuclear Overhauser effects show bound conformations.


500 MHz H, homonuclear, intra-molecular, transferred Nuclear Overhauser Effect measurements have been performed on the bound forms of a classical opiate antagonist, nalorphine and an agonist, levorphanol at their respective binding sites in two different specific anti-opiate monoclonal antibody fragments. Based upon previous studies of opiate conformations… (More)