NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.

@article{Ames2005NMRSO,
  title={NMR structure of the natural killer cell receptor 2B4 (CD244): implications for ligand recognition.},
  author={James B Ames and Vinay V. Vyas and Jacqueline D Lusin and Roy A. Mariuzza},
  journal={Biochemistry},
  year={2005},
  volume={44 17},
  pages={6416-23}
}
2B4, a transmembrane receptor expressed primarily on natural killer (NK) cells and on a subset of CD8(+) T cells, plays an important role in activating NK-mediated cytotoxicity through its interaction with CD48 on target cells. We report here the atomic-resolution structure of the ligand-binding (D1) domain of 2B4 in solution determined by nuclear magnetic resonance (NMR) spectroscopy. The overall main chain structure resembles an immunoglobulin variable (V) domain fold, very similar to that… CONTINUE READING