NMR spectroscopic and analytical ultracentrifuge analysis of membrane protein detergent complexes

@article{Maslennikov2007NMRSA,
  title={NMR spectroscopic and analytical ultracentrifuge analysis of membrane protein detergent complexes},
  author={Innokentiy Maslennikov and Georgia Kefala and Casey D. Johnson and Roland Riek and Senyon Choe and Witek Kwiatkowski},
  journal={BMC Structural Biology},
  year={2007},
  volume={7},
  pages={74 - 74}
}
Structural studies of integral membrane proteins (IMPs) are hampered by inherent difficulties in their heterologous expression and in the purification of solubilized protein-detergent complexes (PDCs). The choice and concentrations of detergents used in an IMP preparation play a critical role in protein homogeneity and are thus important for successful… CONTINUE READING