NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition.

@article{Coutant2007NMRSS,
  title={NMR solution structure of neurotensin in membrane-mimetic environments: molecular basis for neurotensin receptor recognition.},
  author={J{\'e}r{\^o}me Coutant and Patrick A. Curmi and Flavio Toma and J. C. Monti},
  journal={Biochemistry},
  year={2007},
  volume={46 19},
  pages={5656-63}
}
Neurotensin (NT) is a 13-residue neuropeptide that exerts multiple biological functions in the central and peripheral nervous system. Little is known about the structure of this neuropeptide, and what is known only concerns its C-terminal part. We determined here for the first time the structure of the full-length NT in membrane-mimicking environments by means of classical proton-proton distance constraints derived from solution-state NMR spectroscopy. NT was found to have a structure at both… CONTINUE READING