NMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tails.

@article{Bhunia2009NMRSC,
  title={NMR solution conformations and interactions of integrin alphaLbeta2 cytoplasmic tails.},
  author={Anirban Bhunia and Xiao-Yan Tang and Harini Mohanram and Suet-Mien Tan and Surajit Bhattacharjya},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 6},
  pages={
          3873-84
        }
}
The integrins are bi-directional signal transducers. Devoid of enzymatic activity, the integrin cytoplasmic tail serves as a hub for the recruitment of cytosolic proteins, and many of these are signaling molecules. The leukocyte-restricted integrin alphaLbeta2 is essential for the adhesion, migration, and proliferation of leukocytes. Here we report solution conformations and interactions of the alphaLbeta2 cytoplasmic tails by NMR analyses. The alphaL tail is characterized by three helical… CONTINUE READING
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