NMR solution conformation of heparin-derived hexasaccharide.

  title={NMR solution conformation of heparin-derived hexasaccharide.},
  author={Dmitri V. Mikhailov and Robert J. Linhardt and Kevin H. Mayo},
  journal={The Biochemical journal},
  volume={328 ( Pt 1)},
The solution conformation of homogeneous, heparin-derived hexasaccharide (residues A, B, C, D, E, F) has been investigated by using 1H-NMR spectroscopy. Intra-ring conformations have been defined by J-coupling constants and inter-proton nuclear Overhauser effects (NOEs), and the orientation of one ring with respect to the other has been defined by inter-ring NOEs. NOE-based conformational modelling has been done by using the iterative relaxation matrix approach (IRMA), restrained energy… CONTINUE READING

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