NMR measurement of brain oxidative metabolism in monkeys using 13C-labeled glucose without a 13C radiofrequency channel.

@article{Boumezbeur2004NMRMO,
  title={NMR measurement of brain oxidative metabolism in monkeys using 13C-labeled glucose without a 13C radiofrequency channel.},
  author={Fawzi Boumezbeur and Laurent Besret and Julien Valette and Françoise Vaufrey and P E Henry and Velislav Slavov and E. Giacomini and Philippe Hantraye and Gilles R. Bloch and Vincent Lebon},
  journal={Magnetic resonance in medicine},
  year={2004},
  volume={52 1},
  pages={33-40}
}
We detected glutamate C4 and C3 labeling in the monkey brain during an infusion of [U-13C6]glucose, using a simple 1H PRESS sequence without 13C editing or decoupling. Point-resolved spectroscopy (PRESS) spectra revealed decreases in 12C-bonded protons, and increases in 13C-bonded protons of glutamate. To take full advantage of the simultaneous detection of 12C- and 13C-bonded protons, we implemented a quantitation procedure to properly measure both glutamate C4 and C3 enrichments. This… CONTINUE READING

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