NMR mapping of the highly flexible regions of 13C/15N-labeled antibody TTAC-0001-Fab.

@article{Cha2020NMRMO,
  title={NMR mapping of the highly flexible regions of 13C/15N-labeled antibody TTAC-0001-Fab.},
  author={S. Cha and W. Lee and Joonhyeok Choi and Jong-Geun Jeong and Ju Ryoung Nam and JiHong Kim and Hak-Nam Kim and Joon-Hwa Lee and Jin-San Yoo and K. Ryu},
  journal={Journal of biomolecular NMR},
  year={2020}
}
  • S. Cha, W. Lee, +7 authors K. Ryu
  • Published 2020
  • Chemistry, Medicine
  • Journal of biomolecular NMR
Monoclonal antibody (mAb) drugs are clinically important for the treatment of various diseases. TTAC-0001 is under development as a new anti-cancer antibody drug targeting VEGFR-2. As the less severe toxicity of TTAC-0001 compared to Bevacizumab, likely due to the decreased in vivo half-life, seems to be related to its structural flexibility, it is important to map the exact flexible regions. Although the 13C/15N-labeled protein is required for NMR analyses, it is difficult to obtain antibody… Expand

References

SHOWING 1-10 OF 35 REFERENCES
Backbone resonance assignments of the Escherichia coli 62 kDa protein, Hsp31
Pharmacokinetics of monoclonal antibodies and Fc-fusion proteins
Protein dynamics and function from solution state NMR spectroscopy
...
1
2
3
4
...