NMR identification of ligands of aminoglycoside resistance enzymes

Abstract

Bacterial resistance to aminoglycosides is mainly the result of enzyme-catalysed chemical modifications of these antibiotics, which prevents their binding to their target. In order to circumvent this mechanism, an attractive possibility would be to block these enzymes, using selective inhibitors. This work describes a rational strategy aimed at isolating… (More)

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@inproceedings{Maurice2017NMRIO, title={NMR identification of ligands of aminoglycoside resistance enzymes}, author={Fr{\'e}d{\'e}rique Maurice and Guillaume B{\'e}gis and Laurent Micouin and F. Dardel}, year={2017} }