NMR experiments reveal the molecular basis of receptor recognition by a calicivirus.

@article{Rademacher2008NMRER,
  title={NMR experiments reveal the molecular basis of receptor recognition by a calicivirus.},
  author={Christoph Rademacher and N. Rama Krishna and Monica Palcic and Francisco Vargas Parra and Thomas Peters},
  journal={Journal of the American Chemical Society},
  year={2008},
  volume={130 11},
  pages={3669-75}
}
The analysis of virus-receptor interactions at atomic resolution is of fundamental importance to understand infection processes, and to establish novel anti-viral therapies. As an example, rabbit hemorrhagic disease virus (RHDV), a member of the Caliciviridae family and considered as an "emerging" virus, attaches to histo-blood group antigens (HBGA) on the surface of adult rabbit epithelial cells of the upper respiratory and digestive tracts. It appears that this attachment is a key step in the… CONTINUE READING

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