NMR characterization of the binding properties and conformation of glycosaminoglycans interacting with interleukin-10.

@article{Knze2014NMRCO,
  title={NMR characterization of the binding properties and conformation of glycosaminoglycans interacting with interleukin-10.},
  author={Georg K{\"u}nze and Jan-Philip Gehrcke and M. Teresa Pisabarro and Daniel Huster},
  journal={Glycobiology},
  year={2014},
  volume={24 11},
  pages={1036-49}
}
The cytokine interleukin-10 (IL-10) is an important regulator of the host immune system with both pro- and anti-inflammatory functions. Glycosaminoglycans (GAGs) play a decisive role in the biology of many growth factors, e.g., for receptor binding or protection from proteolytic degradation. GAGs of the extracellular matrix inhibit IL-10 signaling, however, the molecular mechanism is so far unknown. Here, we studied the interaction between GAGs and IL-10 using a combination of nuclear magnetic… CONTINUE READING