NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments

@article{Rademacher2010NMRbasedEO,
  title={NMR-based exploration of the acceptor binding site of human blood group B galactosyltransferase with molecular fragments},
  author={Christoph Rademacher and J. Landstr{\"o}m and Nora Sindhuwinata and Monica Palcic and Goeran Widmalm and Thomas Peters},
  journal={Glycoconjugate Journal},
  year={2010},
  volume={27},
  pages={349-358}
}
A substantial body of work has been devoted to the design and synthesis of glycosyltransferase inhibitors. A major obstacle has always been the demanding chemistry. Therefore, only few potent and selective inhibitors are known to date. Glycosyltransferases possess two distinct binding sites, one for the donor substrate, and one for the acceptor substrate. In many cases binding to the donor site is well defined but data for acceptor binding is sparse. In particular, acceptor binding sites are… CONTINUE READING
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