NMR-based characterization of phenothiazines as a RNA binding scaffold.

@article{Mayer2004NMRbasedCO,
  title={NMR-based characterization of phenothiazines as a RNA binding scaffold.},
  author={Moriz Mayer and Thomas L. James},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 13},
  pages={4453-60}
}
Phenothiazines were identified by virtual screening as promising ligands for HIV-1 TAR RNA and A-site ribosomal RNA, and binding in each case was verified experimentally. Consequently, since phenothiazines generally possess high bioavailability and low toxicity, we used several NMR techniques to explore the binding characteristics of acetopromazine with a… CONTINUE READING