NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells

  title={NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells},
  author={C. Chen and J. Gao and T. Wang and Cong Guo and Y. Yan and Chao-yi Mao and Liwei Gu and Y. Yang and Zhong-feng Li and A. Liu},
  journal={Scientific Reports},
  • C. Chen, J. Gao, +7 authors A. Liu
  • Published 2018
  • Chemistry, Medicine
  • Scientific Reports
  • Emodin is a natural anthraquinone derivative that is present in various herbal preparations. The pharmacological effects of emodin include anticancer, hepatoprotective, anti-inflammatory, antioxidant and even antimicrobial activities. However, emodin also has been reported to induce hepatotoxicity, nephrotoxicity, genotoxicity and reproductive toxicity. The mechanism of emodin’s adverse effects is complicated and currently not well understood. This study aimed to establish a cell metabonomic… CONTINUE READING
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