NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water.

@article{Alaa2006NMRAA,
  title={NMR and alanine scan studies of glucose-dependent insulinotropic polypeptide in water.},
  author={I{\~n}igo Ala{\~n}a and Jeremy C. Parker and Victor A Gault and Peter Raymond Flatt and Finbarr P M O'harte and J. Paul G. Malthouse and Chandralal M. Hewage},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 24},
  pages={16370-6}
}
Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates the secretion of insulin after ingestion of food. GIP also promotes the synthesis of fatty acids in adipose tissue. Therefore, it is not surprising that numerous literature reports have shown that GIP is linked to diabetes and obesity-related diseases. In this study, we present the solution structure of GIP in water determined by NMR spectroscopy. The calculated structure is characterized by the presence… CONTINUE READING