Corpus ID: 1772785

NMR analysis of duplex d(CGCGATCGCG)2 modified by Lambda- and Delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study.

@article{Myari2007NMRAO,
  title={NMR analysis of duplex d(CGCGATCGCG)2 modified by Lambda- and Delta-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study.},
  author={A. Myari and N. Hadjiliadis and A. Garoufis and J. Malina and V. Brabec},
  journal={Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry},
  year={2007},
  volume={12 3},
  pages={
          279-92
        }
}
  • A. Myari, N. Hadjiliadis, +2 authors V. Brabec
  • Published 2007
  • Medicine
  • Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry
  • The interaction of the diastereomeric complexes Lambda-[Ru(bpy)2(m-GHK)]Cl2 and Delta-[Ru(bpy)2(m-GHK)]Cl2 (bpy is 2,2'-bipyridine, GHK is glycine-L-histidine-L-lysine) with the deoxynucleotide duplex d(5'-CGCGATCGCG)2 was studied by means of 1H NMR spectroscopy. At a Delta-isomer to DNA ratio of 1:1, significant shifts for the metal complex are observed, whereas there is negligible effect on the oligonucleotide protons and only one intermolecular nuclear Overhauser effect (NOE) is present at… CONTINUE READING