NMR analysis of duplex d(CGCGATCGCG)2 modified by Λ- and Δ-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study

@article{Myari2006NMRAO,
  title={NMR analysis of duplex d(CGCGATCGCG)2 modified by Λ- and Δ-[Ru(bpy)2(m-GHK)]Cl2 and DNA photocleavage study},
  author={A. Myari and N. Hadjiliadis and A. Garoufis and J. Malina and V. Brabec},
  journal={JBIC Journal of Biological Inorganic Chemistry},
  year={2006},
  volume={12},
  pages={279-292}
}
  • A. Myari, N. Hadjiliadis, +2 authors V. Brabec
  • Published 2006
  • JBIC Journal of Biological Inorganic Chemistry
    • The interaction of the diastereomeric complexes Λ-[Ru(bpy)2(m-GHK)]Cl2 and Δ-[Ru(bpy)2(m-GHK)]Cl2 (bpy is 2,2′-bipyridine, GHK is glycine–l-histidine–l-lysine) with the deoxynucleotide duplex d(5′-CGCGATCGCG)2 was studied by means of 1H NMR spectroscopy. At a Δ-isomer to DNA ratio of 1:1, significant shifts for the metal complex are observed, whereas there is negligible effect on the oligonucleotide protons and only one intermolecular nuclear Overhauser effect (NOE) is present at the 2D nuclear… CONTINUE READING
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