NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency

@article{Harvey2018NMRSO,
  title={NMR Structure of μ-Conotoxin GIIIC: Leucine 18 Induces Local Repacking of the N-Terminus Resulting in Reduced NaV Channel Potency},
  author={P. Harvey and N. Kurniawan and Rocio K. Finol-Urdaneta and Jeffrey R McArthur and Dorien Van Lysebetten and Thomas S Dash and J. Hill and David John Adams and T. Durek and D. Craik},
  journal={Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry},
  year={2018},
  volume={23}
}
  • P. Harvey, N. Kurniawan, +7 authors D. Craik
  • Published 2018
  • Chemistry, Medicine
  • Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
  • μ-Conotoxins are potent and highly specific peptide blockers of voltage-gated sodium channels. In this study, the solution structure of μ-conotoxin GIIIC was determined using 2D NMR spectroscopy and simulated annealing calculations. Despite high sequence similarity, GIIIC adopts a three-dimensional structure that differs from the previously observed conformation of μ-conotoxins GIIIA and GIIIB due to the presence of a bulky, non-polar leucine residue at position 18. The side chain of L18 is… CONTINUE READING
    1 Citations

    Figures, Tables, and Topics from this paper.

    In vitro and in silico insights into tyrosinase inhibitors with (E)-benzylidene-1-indanone derivatives
    • 3

    References

    SHOWING 1-10 OF 45 REFERENCES
    Three-dimensional solution structure of mu-conotoxin GIIIB, a specific blocker of skeletal muscle sodium channels.
    • 80
    Solution Structure of μ-Conotoxin PIIIA, a Preferential Inhibitor of Persistent Tetrodotoxin-sensitive Sodium Channels*
    • 63
    • PDF
    Structural Basis for Tetrodotoxin-resistant Sodium Channel Binding by μ-Conotoxin SmIIIA*
    • 46
    • PDF
    Mammalian neuronal sodium channel blocker μ-conotoxin BuIIIB has a structured N-terminus that influences potency.
    • 16
    Clockwise Domain Arrangement of the Sodium Channel Revealed by μ-Conotoxin (GIIIA) Docking Orientation*
    • 88
    • Highly Influential
    • PDF
    Structure and function of μ-conotoxins, peptide-based sodium channel blockers with analgesic activity.
    • 28