NMR Metabolomics Reveals Metabolism-Mediated Protective Effects in Liver (HepG2) Cells Exposed to Subtoxic Levels of Silver Nanoparticles.

@article{Carrola2018NMRMR,
  title={NMR Metabolomics Reveals Metabolism-Mediated Protective Effects in Liver (HepG2) Cells Exposed to Subtoxic Levels of Silver Nanoparticles.},
  author={Joana Carolina Quintela Carrola and Ricardo J. B. Pinto and Maryam Nasirpour and Carmen S. R. Freire and Ana M. Gil and Conceiç{\~a}o Santos and Helena Oliveira and Iola F. Duarte},
  journal={Journal of proteome research},
  year={2018},
  volume={17 4},
  pages={
          1636-1646
        }
}
The expansion of biomedical and therapeutic applications of silver nanoparticles (AgNPs) raises the need to further understand their biological effects on human cells. In this work, NMR metabolomics has been applied to reveal the metabolic effects of AgNPs toward human hepatoma (HepG2) cells, which are relevant with respect to nanoparticle accumulation and detoxification. Cellular responses to widely disseminated citrate-coated AgNPs (Cit30) and to emergent biogenic AgNPs prepared using an… 
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