NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging

@article{Lu2011NMRDO,
  title={NMR Detection of Structures in the HIV-1 5′-Leader RNA That Regulate Genome Packaging},
  author={Kun Lu and X. Heng and Lianko Garyu and S. Monti and Eric L. Garcia and S. Kharytonchyk and Bilguujin Dorjsuren and Gowry Kulandaivel and S. Jones and Atheeth Hiremath and S. Divakaruni and Courtney LaCotti and Shawn Barton and Daniel Tummillo and Azra Hosic and Kedy Edme and Sara Albrecht and A. Telesnitsky and M. Summers},
  journal={Science},
  year={2011},
  volume={334},
  pages={242 - 245}
}
The 5'-leader of the HIV-1 genome regulates multiple functions during viral replication via mechanisms that have yet to be established. [...] Key Method We developed a nuclear magnetic resonance approach that enabled direct detection of structural elements within the intact leader (712-nucleotide dimer) that are critical for genome packaging. Residues spanning the gag start codon (AUG) form a hairpin in the monomeric leader and base pair with residues of the unique-5' region (U5) in the dimer. U5:AUG formation…Expand
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In Vivo SELEX of Single-Stranded Domains in the HIV-1 Leader RNA
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